iBio, Inc.

9 Innovation Way, Suite 100

Newark, Delaware 19711

March 14, 2011

VIA EDGAR

U.S. Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549

Re:       iBio, Inc.
Amendment No. 3 on Form S-3
to Registration Statement on Form S-1
File No. 333-171315         

Ladies and Gentlemen:

iBio, Inc. (the “Company”) hereby submits in electronic format for filing with the U.S. Securities and Exchange Commission (the “SEC”) one complete copy of Amendment No. 3 on Form S-3 (the “Amendment”) to the captioned Registration Statement on Form S-1, File No. 333-171315, filed with the SEC on December 21, 2010, as amended by Amendment No. 1 thereto, filed with the SEC on January 27, 2011, and Amendment No. 2 thereto, filed with the SEC on March 7, 2011 (as amended, the “Registration Statement”), for the registration of shares of the Company’s common stock to be offered by holders of common stock and warrants to purchase common stock, including one complete copy of the exhibits listed in the Amendment as filed therewith.

The Amendment responds to the comments received from the staff of the SEC by letter dated March 11, 2011.

To facilitate the staff’s review, we have set forth the text of the single comment from the letter in italics, followed by the Company’s response.

Comment 1: We note your response to our February 23, 2011 letter and your revised disclosure in your amended filing and reissue our comment in part. Please expand your disclosure on page 18 under the heading “Plan of Distribution” to specifically identify Messrs. Kay and DeSantis, Kobus Investments, LLC and BioMed Innvestments, LLC as underwriters. As Messrs. Kay and DeSantis, Kobus Investments, LLC and BioMed Innvestments, LLC have been determined to be underwriters engaged in a distribution, it is not appropriate to disclose that, as with the other selling stockholders, they “may be deemed” to be underwriters.