IBIO, INC.

600 Madison Avenue, Suite 1601

New York, NY 10022-1737

VIA EDGAR

June 20, 2018

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549

Attention:

Registration Statement on Form S-1 (File No. 333-224620)

Acceleration Request

Ladies and Gentlemen:

Pursuant to Rule 461, iBio, Inc. (the “Company”) hereby requests the Securities and Exchange Commission to accelerate the effective date of the above-referenced Registration Statement and declare the Registration Statement effective as of 5:00 p.m., Washington, D.C. time, on Thursday, June 21, 2018 or as soon thereafter as practicable.