Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Checkbox checked   Rule 13d-1(b)
Checkbox not checked   Rule 13d-1(c)
Checkbox not checked   Rule 13d-1(d)






SCHEDULE 13G




Comment for Type of Reporting Person:  (1) The figures in Items 6, 8, and 9 include (i) 617,327 shares of common stock ("Common Stock") of IBIO, Inc. (the "Issuer") held by Ikarian Healthcare Master Fund, L.P., a Cayman Islands exempted limited partnership (the "Fund"), and certain separately managed accounts (see Item 2 for more information); and (ii) 533,724 shares of Common Stock that may be acquired by the Reporting Persons within 60 days, subject to the Beneficial Ownership Limitation (as defined hereafter), upon the exercise of certain pre-funded warrants and common warrants (the "Warrants") held by the Reporting Persons. Pursuant to the terms of the Warrants, the Issuer may not effect any exercise of the Warrants, and a holder may not exercise any Warrants, to the extent that after giving effect to such issuance after exercise, the aggregate number of shares of Common Stock then beneficially owned by the Reporting Persons would exceed 4.99% of the outstanding shares of Common Stock (the "Beneficial Ownership Limitation"). (2) The figure in Item 11 is based upon (i) 533,724 shares of Common Stock that may be acquired by the Reporting Persons within 60 days upon the conversion of the Warrants up to the Beneficial Ownership Limitation; and (ii) 22,487,308 shares of Common Stock outstanding as of November 10, 2025, as disclosed in the Issuer's quarterly report on Form 10-Q for the quarterly period ended September 30, 2025, filed with the U.S. Securities and Exchange Commission (the "SEC") on November 12, 2025.


SCHEDULE 13G




Comment for Type of Reporting Person:  (1) The figures in Items 6, 8, and 9 include (i) 617,327 shares of Common Stock of the Issuer held by the Fund and certain separately managed accounts (see Item 2 for more information); and (ii) 533,724 shares of Common Stock that may be acquired by the Reporting Persons within 60 days, subject to the Beneficial Ownership Limitation, upon the exercise of the Warrants held by the Reporting Persons. (2) The figure in Item 11 is based upon (i) 533,724 shares of Common Stock that may be acquired by the Reporting Persons within 60 days upon the conversion of the Warrants up to the Beneficial Ownership Limitation; and (ii) 22,487,308 shares of Common Stock outstanding as of November 10, 2025, as disclosed in the Issuer's quarterly report on Form 10-Q for the quarterly period ended September 30, 2025, filed with the SEC on November 12, 2025.


SCHEDULE 13G



 
Ikarian Capital, LLC
 
Signature:/s/ Neil Shahrestani
Name/Title:Neil Shahrestani, Sole Manager
Date:11/14/2025
 
Neil Shahrestani
 
Signature:/s/ Neil Shahrestani
Name/Title:Neil Shahrestani
Date:11/14/2025

Comments accompanying signature:  A Joint Filing Agreement is incorporated herein by reference to Exhibit 99.1 to the Schedule 13G filed on November 14, 2024 by the Reporting Persons with the SEC.